Calderdale and Huddersfield NHS Foundation Trust Lozenge

Publications - Trust Involvement

Cancer Research - Breast

Breast Cancer Surgery During the Covid-19 Pandemic Peak in the UK: Operative Outcomes

BREAKOUT - International Breast Cancer Biomarker, Standard of Care and Real World Outcomes Study

Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial.

PERUSE (MO28047): A Multicentre, Openlabel, Single-arm Study of Pertuzumab in Combination with Trastuzumab and a Taxane in First Line Treatment with Her2-Postive Advanced (Metastatic or Locally Advanced Recurrent) Breast cancer.

Cancer Research - Colorectal

The Fast Track FIT study: diagnostic accuracy of faecal immunochemical test for haemoglobin in patients with suspected colorectal cancer.

FOxTROT: Fluoropyrimidine, Oxaliplatin & Targeted Receptor pre-Operative Therapy for colon cancer. A randomised trial assessing whether preoperative chemotherapy and/or an anti-EGFR monoclonal antibody improves outcome in high-risk operable colon cancer.

Cancer Research - Gynaecological

DESKTOP III: A Randomized Multicenter Study to Compare the Efficacy of Additional Tumor Debulking Surgery Versus Chemotherapy Alone for Recurrent Platinum-Sensitive ovarian Cancer.

Results of the ICON8B trial | MRC Clinical Trials Unit at UCL

Cancer Research - Haematology

The MPN Experimental Assessment of Symptoms by Utilizing Repeatitive Evaluation (MEASURES)

Cancer Research - Lung

STOMP: A randomized, double-blind, placebo-controlled phase II trial to evaluate use of the PARP inhibitor olaparib as maintenance treatment for patients small cell lung cancer (SCLC).

Cancer Research - Upper Gastrointestinal

ESPAC-4 : EUROPEAN STUDY GROUP FOR PANCREATIC CANCER - TRIAL 4. Combination versus single agent chemotherapy in resectable pancreatic ductal and peri-ampullary cancers.

GO2 Phase 3 Randomized Clinical Trial - Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer.

Cancer Research - Urology

Long Term Results of the POUT trial: PeriOperative chemotherapy or sUrveillance in upper Tract urothelial cancer https://doi.org/10.1200/JCO.23.01659

POUT LT results summary for participants 21.02.2024

Cardiovascular Research

EMIT-AF/VTE: Edoxaban management in diagnostic and therapeutic procedures

Covid-19 Research

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK.

The RECOVERY Trial - Azithromycin Treatment

The RECOVERY Trial - Dexamethasone Treatment

The RECOVERY Trial - Monoclonal Antibody Combination

SIREN (Sarscov2 Immunity & REinfection EvaluatioN): The impact of detectable anti SARS-COV2 antibody on the incidence of COVID-19 in healthcare workers

CLARITY: impaCt of bioLogic therApy on saRs-cov-2 Infection & immuniTY

Psychological impact of Covid-19 Study

Diabetes Research

SLEEP T2D Trial: https://onlinelibrary.wiley.com/doi/10.1111/dme.70051

Health Services & Delivery Research

Evaluation of the Impact of High-Intensity Specialist-Led Acute Care (HiSLAC) on Emergency Medical Admissions to NHS Hospitals at Weekends.

Scaling Up Quality Improvement for Surgical Teams (QIST)

Ageing Well Dying Well

Musculoskeletal Research

Identification of Key Genetic Effects of Ankylosing Spondylitis.

National Early Warning Score (NEWS) 2

Investigation into the predictive capability for mortality and the trigger points of the National Early Warning Score 2 (NEWS2) in emergency department patients.

Obstetrics & Gynaecology Research

PRISM: A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy

Associations between symptoms of sleep-disordered breathing and maternal sleep patterns with late stillbirth: Findings from an individual participant data meta-analysis

The establishment of breastfeeding in the small-for-gestational-age baby

The Co-Development & Feasibility-Testing of an Innovative Digital Animation Intervention (DAISI) to Reduce the Risk of Maternal Sepsis in the Postnatal Period

Association of Supine Going-to-Sleep Position in Late Pregnancy With Reduced Birth Rate

UK Obstetric Surveillance System (UKOSS) SARS-CoV-2 Infection in Pregnancy Collaborative Group

UKOSS At A Glance

Cerclage suture type to prevent pregnancy loss in women requiring a vaginal cervical cerclage: the C-STICH RCT

Quality improvement interventions to increase the uptake of magnesium sulphate in preterm deliveries for the prevention of cerebral palsy (PReCePT study): a cluster randomised controlled trial.

Scaling up an intervention to protect preterm infants from neurodevelopmental disabilities — findings from a qualitative process evaluation comparing standard with enhanced quality improvement support packages for maternity units in England.

Ophthalmology Research

Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial

Paediatric Research

Study of Preterm Infants and Neurodevelopmental Genes (SPRING)

OPTI-Prem: Optimising neonatal service provision for preterm babies born between 27 and 31 weeks of gestation in England using national data, qualitative research and economic analysis.

Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome: the PREDNOS 2 study.

Respiratory Research

Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC)

Sexual Health Research

C2C: “Real-World Utilization and Effectiveness of Long-Acting Cabotegravir + Rilpivirine in Virologically Suppressed Treatment Experienced Individuals in Europe: Data from COMBINE-2 Cohort Study

Trauma & Orthopaedic Research

Acute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial | The BMJ

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