Current Research

Yorkshire Cancer Research Bowel Cancer Improvement Program: Does intensive multidisciplinary team intervention improve bowel cancer outcomes in Yorkshire.

Principal Investigator (PI): Ms Paula Pickersgill 

OnCoRe: Oncological Outcomes after Clinical Complete Response (cCR) in patients with rectal cancer.

Principal Investigator (PI): Miss Tamsyn Grey

FOxTROT2: Personalising neo-adjuvant Chemotherapy in Locally advanced but operable colon cancer. A randomised trial programme.

Principal Investigator (PI): Dr Sam Turnbull 

FOxTROT3: A phase III randomized trial evaluating neoadjuvant chemotherapy with mFOLFOXIRI  compared with neoadjuvant OxFp in patients with locally advanced but operable colon cancer

Principal Investigator (PI): Dr Sam Turnbull

ARIEL: A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer (aCRC) with wild-type RAS and right primary tumour location (right-PTL).

Principal Investigator (PI): Dr Sam Turnbull

TRACC-C: Tracking mutations in cell free tumour DNA to predict relapse in early colorectal cancer.

Principal Investigator (PI): Dr Sam Turnbull

CML Registry: The study programme to investigate modern trends in Chronic Myeloid Leukemia (CML).

Principal Investigator (PI): Dr Kate Rothwell

FLAIR: This is a phase III, multicentre, randomised, controlled, open, parallel group trial in patients with previously untreated CLL.

Principal Investigator (PI): Dr Kate Rothwell

EUMDS: A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes

Principal Investigator (PI): Dr Kate Rothwell

MYELOMA XIV (FITNESS): A phase III trial to compare standard and frailty-adjusted induction therapy with ixazomib, lenalidomide and dexamethasone (IRD) and maintenance lenalidomide (R) to lenalidomide plus ixazomib (R+I).

Principal Investigator (PI): Dr Sylvia Feyler

RADAR (UK-MRA Myeloma XV): Risk-Adapted therapy Directed According to Response comparing treatment escalation and de-escalation strategies in newly diagnosed patients with multiple myeloma (NDMM) suitable for stem cell transplant (TE).

Principal Investigator (PI): Dr Sylvia Feyler

IONA-MM: A non-interventional, multinational, observational study with isatuximab in patients with relapsed and/or refractory multiple myeloma (RRMM).

Prinicipal Investigator (PI): Dr Sylvia Feyler

BGB-3111-308: A Phase 3 Randomized, Open-Label, Multicenter Study of Zanubrutinib (BGB 3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma.

Prinicipal Investigator (PI): Dr Sylvia Feyler

COSMOS: Characterising risk and biology Of Smouldering Myeloma for early detection Of Symptomatic myeloma.

Prinicipal Investigator (PI): Dr Sylvia Feyler

NIMBLE: Nodule Immunophenotyping biomarker for lung cancer early diagnosis study.

Principal Investigator (PI): Dr Steven Thomas

REFINE-LUNG: A randomised open-label phase III trial of Reduced Frequency pembrolizumab immuNothErapy for first line treatment of patients with advanced non-small cell lung cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design.

Principal Investigator (PI): Dr Emma Rathbone

IMREAL: A NON-INTERVENTIONAL, MULTICENTER, MULTIPLE COHORT STUDY INVESTIGATING THE OUTCOMES AND SAFETY OF ATEZOLIZUMAB UNDER REALWORLD CONDITIONS IN PATIENTS TREATED IN ROUTINE CLINICAL PRACTICE.

Principal Investigator (PI): Dr Nick Brown

STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy.

Principal Investigator (PI): Dr Uschi Hofmann

BC-RECON: Diagnosing Bladder Cancer- evaluating the role of a urinary biomarker test in the Reconfiguration of the haematuria clinic investigations.

Principal Investigator (PI): Mr Tahir Qayyum

ICI Genetics: Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity.  Participants recruited from all forms of cancer. 

Principal Investigator (PI): Dr Emma Rathbone

APPROACH: An app for health & wellbeing after cancer – a randomised controlled trial.

Prinicipal Investigator (PI): Nicky Hill

BADBIR: British Association of Dermatologists Biologics and Immunomodulators Register

Principal Investigator (PI): Tracy Tatchell-Adams

IBD BioResource: The UK Inflammatory Bowel Disease Bioresource: Progressing from Genetics to Function and Clinical Translation in Crohn's Disease & Ulcerative Colitis.

Principal Investigator (PI): Dr Sunil Sonwalker

GONDOMAR: Goals, Needs and outcome Determinants Of Multimodal therapy in Perianal Crohn's fistula.

Principal Investigator (PI): Dr Mohammed Allah-Ditta

ABX464-105: A randomized, double-blind, placebo-controlled, multicenter phase III study to evaluate the efficacy and safety of ABX464 once daily for induction treatment in subjects with moderately to severely active ulcerative colitis.

Principal Investigator (PI): Dr Mohamed Yousif

MK7240-001: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to Evaluate the Efficacy and Safety of MK-7240 in Participants with Moderately to Severely Active Ulcerative Colitis.

Principal Investigator (PI): Dr Mohamed Yousif

MK7240-008: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to
Evaluate the Efficacy and Safety of Tulisokibart in Participants with Moderately to Severely
Active Crohn’s Disease.

Principal Investigator (PI): Dr Mohamed Yousif

DURATION-UTI: Impact of duration of antibiotic treatment on symptoms, recovery and antibiotic resistance in adult women with urinary tract infections (UTIs): a randomised controlled trial.

Principal Investigator (PI): Dr Rangaprasad Karadi

BSRBR: Toxicity from biologic therapy

Principal Investigator (PI): Dr Omer Sharif 

IMID: Immune-Mediated Inflammatory Diseases BioResource - Part of NIHR BioResource.

Principal Investigator (PI): Dr Omer Sharif

Validation of translational biomarkers of neuropathic pain: RECRUITMENT SUSPENDED The Identification and validation of translational biomarkers of Neuropathic Pain.  A matched cohort study investigating biomarkers in several sub-group populations of Neuropathic Pain.

Principal Investigator (PI): Dr Rajesh Menon

MIDI: Deep Learning for Identification of Abnormalities on Head MRI.

Principal Investigator (PI): Mrs Georgina Turner

TTTS Registry: A physician-run Multiple Pregnancy Registry in collaboration with the Twin & Multiple Births Association (TAMBA), designed to serve the interests of patients while overcoming challenges of sharing data over great distances while protecting patient privacy.

Principal Investigator (PI): Dr Fifydani Shamsudin

CAPE: Calcium Supplementation for Prevention of Pre-eclampsia in High Risk Women.

Principal Investigator (PI): Dr Fifydani Shamsudin

GBS3: The clinical and cost-effectiveness of testing for Group B Streptococcus: a cluster randomised trial with economic and acceptability evaluations.

Prinicipal Investigator (PI): Dr Julie Goddard

CHAPTER: CHildbirth Acquired Perineal TRauma Study A cohort study

Principal Investigator (PI): Dr Tina Verghese

SUNNY: A Randomised Controlled Trial to investigate the Feasibility and Acceptability of SnacktivityTM in Pregnant Women. 

Principal Investigator (PI): Rebecca Leon

MINESS 20-28: Mothers Working to Prevent Early Stillbirth Study 20-28.

Principal Investigator (PI): Rebecca Leon

OBS UK: Clinical and cost-effectiveness of a maternity quality improvement programme to reduce excess bleeding and need for transfusion after childbirth.

Principal Investigator (PI): Mohamed Wahby

ATHENA: Optical Coherence Tomography Angiography for the detection of Neovascular Age-related Macular Degeneration: a Comprehensive Diagnostic Accuracy Study.

Principal Investigator (PI): Dr Indra Dias

Cleft Collective: Cohort Studies - a large DNA backed prospective resource for the study of the genetic and environmental determinants of cleft lip and/or palate and the long term outcomes in children with cleft lip and/or palate.

Principal Investigator (PI): Rebecca Leon

Cystic Fibrosis: Cystic Fibrosis Registry.

Principal Investigator (PI): Dr Amal Elnour

AZTEC-2: Long term follow-up of Azithromycin Therapy for Chronic Lung Disease of Prematurity.

Prinicipal Investigator (PI): Dr Gill Sharpe

CF START: The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF

Principal Investigator (PI): Dr Abdul Mattara

FEED1 - Fluids Exclusively Enteral from Day 1:  A randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30-33 weeks gestational age).

Principal Investigator (PI): Dr Abdul Mattara

WHEAT:  WithHolding Enteral Feeds Around Blood Transfusion – the WHEAT International Trial.

Principal Investigator (PI): Dr James Houston

MAPS: Mental Health Admissions to Paediatric Wards Study - WP2 & WP3. 

Principal Investigator (PI): Angie Salmons

SPIROMAC: SPIROmetry to Manage Asthma in Children.

Principal Investigator (PI): Dr James Houston

NeoGASTRIC: Avoiding routine gastric residual volume measurement in neonatal critical care: a multi-centre randomised controlled trial.

Principal Investigator (PI): Dr Karin Schwarz

RADAR: National Studies of Rare Kidney Diseases

Principal Investigator (PI): Dr Rahul Vundru

ASPECT: Aspirin after hospitalisation with pneumonia to prevent cardiovascular events randomised controlled trial. 

Principal Investigator (PI): Dr Purav Desai

SENSOR: Physiological and environmental data in a remote setting to predict exacerbation events in patients with chronic obstructive pulmonary disease: an observational study

Principal Investigator (PI): Dr Andrew Hardy

DEVA: Dequalinium versus usual care antibiotics for the treatment of bacterial vaginosis.  A multicentre randomised, open label, non-inferiority trial.

Principal Investigator (PI): Dr Emma Street

C2C Combine: Cabotegravir+Rilpivirine LA Regimen-A Prospective Cohort Study to Monitor Effectiveness, Adherence and Resistance

Principal Investigator (PI): Dr Emma Street

OPTIMAS: A randomised, controlled trial considering Optimal Timing of Anticoagulation after an acute ischaemic stroke.

Principal Investigator (PI): Dr Manohar Kini

ENRICH-AF: EdoxabaN foR IntraCranial Haemorrhage survivors with atrial fibrillation.

Principal Investigator (PI): Dr Pratap Rana

MAPS-2: Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial.

Principal Investigator (PI): Dr Syed Ahmad

LIBREXIA STROKE: A Phase 3 Placebo-controlled Study of Milvexian after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack.

Principal Investigator (PI): Dr Tariq Salman

ROSSINI 2: Reduction Of Surgical Site Infection using several Novel Interventions.

Principal Investigator (PI): Mr Muneer Junejo

PQIP Perioperative Quality Improvement Programme: A patient study improving perioperative care through the use of quality data. Gathering and analysis of patient data using the PQIP Database. 

Principal Investigator (PI): Mr Alex Spyridoulias

MEErKAT: Mesenteric Excision and Kono-S Anastomosis Trial

Principal Investigator (PI): Mr Simon Gonsalves

E-BRIC: Early bowel resection for terminal ileal Crohn’s disease: exploring patients’ and clinicians’ perspectives and barriers to implementation.

Principal Investigator (PI): Miss Tamsyn Grey

RECOVER TOGETHER: Improving recovery after bowel cancer surgery: Mixed-method feasibility study of a co-produced information intervention.

Principal Investigator (PI): Miss Claire McDonald

RESPOND study (Rescue for Emergency Surgery Patients Observed to uNdergo acute Deterioration) Work Package 4: A cluster-randomised stepped-wedge Trial of a complex Human Factors intervention.

Principal Investigator (PI): Mr Arin Saha

OCEAN: Optimisation before Crohn’s surgery using Exclusive Enteral Nutrition.

Principal Investigator (PI): Mr Muneer Junejo

PROFHER2: A three-arm randomised controlled trial to assess the effectiveness and cost-effectiveness of reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical care for acute three and four part fractures of the proximal humerus in patients over 65yrs of age - Proximal Fracture Of the Humerus: Evaluation by Randomisation trial No. 2.

Principal Investigator (PI): Mr Neil Pennington

WHITE PLATFORM - LIT: World Hip Trauma Evaluation Appendix 10 – LIT: Lidocaine Intravenous Trial.

Principal Investigator (PI): Dr Andreea Jimenez

HUSH: The HUmeral SHaft fracture trial: A multi-centre prospective randomised superiority trial of surgical versus non-surgical interventions for humeral shaft fractures in patients aged 18 years or older.

Principal Investigator (PI): Mr Simon Fogerty

DIDACT: Surgery compared with sling immobilisation in the management of adults with a
displaced fracture of the distal clavicle: a multi-centre, pragmatic, parallel group,
non-inferiority, randomised controlled trial.

Principal Investigator (PI): Mr Neil Pennington

REPPORT: REcurrent Patellar dislocation: Personalised therapy or OpeRative Treatment?

Principal Investigator (PI): Mr Osman Riaz

SYNC01: Development of a new Patient Reported Outcome Measure (PROM) to assess patient’s emotional wellbeing and perceptions of Total Knee Replacement surgery for the treatment of knee arthritis.

Principal Investigator (PI): Dr Andreea Jimenez