Current Research

The types of research currently undertaken at the Trust are varied, from complex clinical trials, qualitative health service research, registries, post-marketing surveillance to trainee doctors and students doing low risk, own account studies. Much of this research has been adopted by the National Institute of Health Research, with a small number of commercial/pharmaceutical research making up the rest. 

Cancer Research

Breast

ATNEC: A randomised trial investigating the requirement for axillary treatment, after chemotherapy, for patients with early stage breast cancer.

Principal Investigator (PI): Ms Werbena Hamilton-Burke

 

Colorectal

Yorkshire Cancer Research Bowel Cancer Improvement Program: Does intensive multidisciplinary team intervention improve bowel cancer outcomes in Yorkshire.

Principal Investigator (PI): Ms Paula Pickersgill 

OnCoRe: Oncological Outcomes after Clinical Complete Response (cCR) in patients with rectal cancer.

Principal Investigator (PI): Miss Tamsyn Grey

FOxTROT2: Personalising neo-adjuvant Chemotherapy in Locally advanced but operable colon cancer. A randomised trial programme.

Principal Investigator (PI): Dr Sam Turnbull 

FOxTROT3: A phase III randomized trial evaluating neoadjuvant chemotherapy with mFOLFOXIRI  compared with neoadjuvant OxFp in patients with locally advanced but operable colon cancer

Principal Investigator (PI): Dr Sam Turnbull

ARIEL: A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer (aCRC) with wild-type RAS and right primary tumour location (right-PTL).

Principal Investigator (PI): Dr Sam Turnbull

TRACC-C: Tracking mutations in cell free tumour DNA to predict relapse in early colorectal cancer.

Principal Investigator (PI): Dr Sam Turnbull

Haematology

CML Registry: The study programme to investigate modern trends in Chronic Myeloid Leukemia (CML).

Principal Investigator (PI): Dr Kate Rothwell

EUMDS: A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes

Principal Investigator (PI): Dr Kate Rothwell

RADAR (UK-MRA Myeloma XV): Risk-Adapted therapy Directed According to Response comparing treatment escalation and de-escalation strategies in newly diagnosed patients with multiple myeloma (NDMM) suitable for stem cell transplant (TE).

Principal Investigator (PI): Dr Sylvia Feyler

BGB-3111-308: A Phase 3 Randomized, Open-Label, Multicenter Study of Zanubrutinib (BGB 3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma.

Prinicipal Investigator (PI): Dr Sylvia Feyler

COSMOS: Characterising risk and biology Of Smouldering Myeloma for early detection Of Symptomatic myeloma.

Prinicipal Investigator (PI): Dr Sylvia Feyler

Lung

REFINE-LUNG: A randomised open-label phase III trial of Reduced Frequency pembrolizumab immuNothErapy for first line treatment of patients with advanced non-small cell lung cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design.

Principal Investigator (PI): Dr Emma Rathbone

SUNRAY-01: A Global Pivotal Study in Participants with KRAS G12C-Mutant, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Comparing FirstLine Treatment of LY3537982 and Pembrolizumab vs Placebo and Pembrolizumab in those with PD-L1 expression ≥50% or LY3537982 and Pembrolizumab, Pemetrexed, Platinum vs Placebo and Pembrolizumab, Pemetrexed, Platinum regardless of PD-L1 Expression.

Principal Investigator (PI): Dr Emma Rathbone

Pancreatic

UK-EDI: UK Early Detection Initiative for Pancreatic Cancer. 

Principal Investigator (PI): Dr Sabari Haridass

Urology

BC-RECON: Diagnosing Bladder Cancer- evaluating the role of a urinary biomarker test in the Reconfiguration of the haematuria clinic investigations.

Principal Investigator (PI): Mr Tahir Qayyum

Other

ICI Genetics: Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity.  Participants recruited from all forms of cancer. 

Principal Investigator (PI): Dr Emma Rathbone

APPROACH: An app for health & wellbeing after cancer – a randomised controlled trial.

Prinicipal Investigator (PI): Nicky Hill

Other Specialty Research

Anaesthesia

CRICKET: Critical Events in anaesthetised kids undergoing tracheal intubation – a prospective multi-centre observational study.

Principal Investigator: Dr Michael Moncreiff

Cardiovasular

EASY-AS: A Randomised Controlled Trial of Early valve replacement in severe ASYmptomatic Aortic Stenosis.

Principal Investigator (PI): Dr Hossam Elmahy

AMEND-CRT: Assessment of Mechanical Dyssynchrony as Selection Criterion for Cardiac Resynchronisation Therapy.

Principal Investigator (PI): Dr Hossam Elmahy

EASi-HF: A Phase III double-blind, randomised, parallel-group superiority trial to evaluate efficacy and safety of the combined use of oral BI 690517 and empagliflozin compared with placebo and empagliflozin in participants with symptomatic heart failure (HF: NYHA II-IV) and left ventricular ejection fraction (LVEF) ≥40%.

Principal Investigator (PI): Dr Azeem Sheikh

Critical Care

SIGNET: Statins for Improving Organ Outcome in Transplantation.

Principal Investigator (PI): Dr Paul Knight

MOSAICC: Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury and metabolic acidosis.

Principal Investigator (PI): Dr Aaron Corp

Dermatology

BADBIR: British Association of Dermatologists Biologics and Immunomodulators Register

Principal Investigator (PI): Tracy Tatchell-Adams

Diabetes & Endocrinology

IONIS CORE: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia.

Principal Investigator (PI): Dr Sabari Haridass

ISIS 678354-CS15: An Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients with Severe Hypertriglyceridemia (SHTG).

Principal Investigator (PI): Dr Sabari Haridass

PROTECT: PRegnancy Outcomes using continuous glucose monitoring TEChnology in pregnant women with early-onset Type 2 diabetes.

Principal Investigator (PI): Dr Julie Kway-Tun

Emergency Care

CRASH-4: Intramuscular tranexamic acid for the treatment of symptomatic mild traumatic brain injury in older adults: a randomised, double-blind, placebo-controlled trial.

Principal Investigator (PI): Dr Huw Masson

Gastroenterology

IBD BioResource: The UK Inflammatory Bowel Disease Bioresource: Progressing from Genetics to Function and Clinical Translation in Crohn's Disease & Ulcerative Colitis.

Principal Investigator (PI): Dr Sunil Sonwalker

GONDOMAR: Goals, Needs and outcome Determinants Of Multimodal therapy in Perianal Crohn's fistula.

Principal Investigator (PI): Dr Mohammed Allah-Ditta

ABX464-105: A randomized, double-blind, placebo-controlled, multicenter phase III study to evaluate the efficacy and safety of ABX464 once daily for induction treatment in subjects with moderately to severely active ulcerative colitis.

Principal Investigator (PI): Dr Mohamed Yousif

MK7240-001: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to Evaluate the Efficacy and Safety of MK-7240 in Participants with Moderately to Severely Active Ulcerative Colitis.

Principal Investigator (PI): Dr Mohamed Yousif

MK7240-008: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to
Evaluate the Efficacy and Safety of Tulisokibart in Participants with Moderately to Severely
Active Crohn’s Disease.

Principal Investigator (PI): Dr Mohamed Yousif

Haematology

MDS Registry for newly diagnosed patients: A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes

Principal Investigator (PI): Dr Kate Rothwell

 

Hepatology

PBC Genetics Study: Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis.

rincipal Investigator (PI): Dr Susan Jones

 

Infection

DURATION-UTI: Impact of duration of antibiotic treatment on symptoms, recovery and antibiotic resistance in adult women with urinary tract infections (UTIs): a randomised controlled trial.

Principal Investigator (PI): Dr Rangaprasad Karadi

TILIA: A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen.

Principal Investigator (PI): Dr Yaqoob Ghumro

Musculoskeletal

BSRBR: Toxicity from biologic therapy

Principal Investigator (PI): Dr Omer Sharif 

 

Obstetric & Gynaecology

TTTS Registry: A physician-run Multiple Pregnancy Registry in collaboration with the Twin & Multiple Births Association (TAMBA), designed to serve the interests of patients while overcoming challenges of sharing data over great distances while protecting patient privacy.

Principal Investigator (PI): Dr Fifydani Shamsudin

CAPE: Calcium Supplementation for Prevention of Pre-eclampsia in High Risk Women.

Principal Investigator (PI): Dr Fifydani Shamsudin

MINESS 20-28: Mothers Working to Prevent Early Stillbirth Study 20-28.

Principal Investigator (PI): Rebecca Leon

OBS UK: Clinical and cost-effectiveness of a maternity quality improvement programme to reduce excess bleeding and need for transfusion after childbirth.

Principal Investigator (PI): Mohamed Wahby

Paediatric

Cleft Collective: Cohort Studies - a large DNA backed prospective resource for the study of the genetic and environmental determinants of cleft lip and/or palate and the long term outcomes in children with cleft lip and/or palate.

Principal Investigator (PI): Rebecca Leon

FEED1 - Fluids Exclusively Enteral from Day 1:  A randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30-33 weeks gestational age).

Principal Investigator (PI): Dr Abdul Mattara

WHEAT:  WithHolding Enteral Feeds Around Blood Transfusion – the WHEAT International Trial.

Principal Investigator (PI): Dr James Houston

MAPS: Mental Health Admissions to Paediatric Wards Study - WP2 & WP3. 

Principal Investigator (PI): Angie Salmons

SPIROMAC: SPIROmetry to Manage Asthma in Children.

Principal Investigator (PI): Dr James Houston

NeoGASTRIC: Avoiding routine gastric residual volume measurement in neonatal critical care: a multi-centre randomised controlled trial.

Principal Investigator (PI): Dr Karin Schwarz

Physiotherapy

RaCeR 2: Clinical and cost-effectiveness of individualised (early) patient-directed rehabilitation versus standard rehabilitation after surgical repair of the rotator cuff of the shoulder: a multi-centre, randomised controlled trial with integrated Quintet Recruitment Intervention.

Principal Investigator (PI): Tash Maher

 

Renal & Urogenital

RADAR: National Studies of Rare Kidney Diseases

Principal Investigator (PI): Dr Rahul Vundru

Respiratory

ASPECT: Aspirin after hospitalisation with pneumonia to prevent cardiovascular events randomised controlled trial. 

Principal Investigator (PI): Dr Purav Desai

SENSOR: Physiological and environmental data in a remote setting to predict exacerbation events in patients with chronic obstructive pulmonary disease: an observational study

Principal Investigator (PI): Dr Andrew Hardy

Stroke

MAPS-2: Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial.

Principal Investigator (PI): Dr Syed Ahmad

LIBREXIA STROKE: A Phase 3 Placebo-controlled Study of Milvexian after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack.

Principal Investigator (PI): Dr Tariq Salman

Surgical

MEErKAT: Mesenteric Excision and Kono-S Anastomosis Trial

Principal Investigator (PI): Mr Simon Gonsalves

E-BRIC: Early bowel resection for terminal ileal Crohn’s disease: exploring patients’ and clinicians’ perspectives and barriers to implementation.

Principal Investigator (PI): Miss Tamsyn Grey

RESPOND study (Rescue for Emergency Surgery Patients Observed to uNdergo acute Deterioration) Work Package 4: A cluster-randomised stepped-wedge Trial of a complex Human Factors intervention.

Principal Investigator (PI): Mr Arin Saha

OCEAN: Optimisation before Crohn’s surgery using Exclusive Enteral Nutrition.

Principal Investigator (PI): Mr Muneer Junejo

Trauma & Orthopaedics

DIDACT: Surgery compared with sling immobilisation in the management of adults with a
displaced fracture of the distal clavicle: a multi-centre, pragmatic, parallel group,
non-inferiority, randomised controlled trial.

Principal Investigator (PI): Mr Neil Pennington

REPPORT: REcurrent Patellar dislocation: Personalised therapy or OpeRative Treatment?

Principal Investigator (PI): Mr Osman Riaz

SYNC01: Development of a new Patient Reported Outcome Measure (PROM) to assess patient’s emotional wellbeing and perceptions of Total Knee Replacement surgery for the treatment of knee arthritis.

Principal Investigator (PI): Dr Andreea Jimenez

Studies In Follow-Up

Accident & Emergency

HUSH:The Humeral Shaft Fracture Trial: A multi-centre Prospective Randomised Superiority Trial of Surgical Versus Non-Surgical Interventions for Humeral Shaft Fractures in Patients Aged 18 Years or Older.

Principal Investigator (PI):Mr Simon Fogerty

Cancer

Add-Aspirin: A phase III double-blind placebo-controlled randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.

Principal Investigator (PI): Dr Jo Dent

FAST-Forward: To Identify A 5-Fraction Schedule Of Curative Radiotherapy Delivered In 1 Week That Is At Least As Effective And Safe As The Current UK Standard 15-Fraction Regimen Delivered Over 3 Weeks Following Primary Surgery For Early Breast Cancer.

Principal Investigator (PI): Mr Neil Roberts

FLAIR: Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab, A phase III, multicentre, randomised, controlled, open, parallel group trial in patients with previously untreated CLL.

Principal Investigator (PI): Dr Kate Rothwell

Genetics of Endometrial Cancer: A population based study of genetic predisposition and gene-environment interactions in endometrial cancer.

Principal Investigator (PI): Dr Uschi Hofmann

SKYSCRAPER: A Phase III, Open-label, Randomised Study of Atezolizumab and Tiragolumab Compared with Durvalumab in Patients with Locally Advanced Unresectable Stage III Non-Small-Cell Lung Cancer Who have not progressed After Concurrent Platinum-based Chemo Radiation.

Principal Investigator (PI): Dr Emma Rathbone

HORIZONS:Understanding the impact of cancer diagnosis and treatment.

Principal Investigator (PI): Mrs Georgina Turner

IRAMP: A Study Exploring Research Access for People with Mesothelioma via Interviews with Patients, Carers and Health Care Professionals Who Have Experience of the Condition.

Principle Investigator (PI): Mr Simon Bolton

IMreal: A Non-Interventional, Multicenter, Multiple Cohort Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions In Patients Treated in Routine Clincial Practice.

Principal Investigator (PI):Dr Nick Brown

LI-1: Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI1) Trial.

Principal Investigator (PI): Dr Kate Rothwell

MaPLe:Molecular profiling for lymphoma.

Principle Investigator (PI): Dr Kate Rothwell

Myeloma XII (ACCoRd trial): A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT Consolidation and maintenance strategy in patients with Relapsed multiple myeloma.

Principal Investigator (PI): Dr Sylvia Feyler

Myeloma XIV (FiTNEss): Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma: A phase III trial to compare standard and frailty-adjusted induction therapy with ixazomib, lenalidomide and dexamethasone (IRD) and maintenance lenalidomide (R) to lenalidomide plus ixazomib (R+I).

Principal Investigator (PI): Dr Sylvia Feyler

NIMBLE: Nodule Immunophenotyping biomarker for lung cancer early diagnosis study.

Principal Investigator (PI): Dr Steven Thomas

PATCH: Prostate Adenocarcinoma: TransCutaneous Hormones: A Randomised Controlled Trial of Transcutaneous Oestrogen Patches Versus LHRH Agonists in Prostate Cancer.

Principal Investigator (PI): Dr Uschi Hofmann

POETIC: Trial of Perioperative Endocrine Therapy - Individualising Care.

Principal Investigator (PI): Dr Werbena Hamilton-Burke

PrecisionPanc: Advancing personalised medicine treatment strategies for pancreatic cancer.

Principal Investigator (PI): Dr Emma Rathbone

PRIMETIME: Post-operative avoidance of radiotherapy: biomarker selection of women categorised to be in a very low risk group by IHC4+C.

Principal Investigator (PI): Mr Neil Roberts

PRIMUS 001: An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation.

Principal Investigator (PI): Dr Emma Rathbone

RaNGO: Rare Neoplasms of Gynaecological Origin.

Principal Investigator (PI): Dr Deivasikamani Ramanujam

ROSCO: Response to Optimal Selection of neo-adjuvant Chemotherapy in Operable breast cancer: A randomised phase III, stratified biomarker trial of neo­adjuvant 5-Fluorouracil, Epirubicin and Cyclophosphamide vs Docetaxel and Cyclophosphamide chemotherapy.

Principal Investigator (PI): Dr Deivasikamani Ramanujam

STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy.

Principal Investigator (PI): Dr Uschi Hofmann

MARECA: National study of management of breast cancer locoregional recurrence and oncological outcome.

Principal Investigator (PI): Dr Richard Frame

UKALL 2011: United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011.

Principal Investigator (PI): Dr Gill Sharpe

UNIRAD: Randomized, Double-Blind, Multicentre Phase III Trial Evaluating the Safety and Benefit of Adding Everolimus to Adjuvant Hormone Therapy in Women with Poor Prognosis, ER+ and HER2- Primary Breast Cancer Who Remain Free of Disease.

Principal Investigator (PI): Dr Jo Dent

Cardiovascular

EVAREST:The Use of Blood Biomarkers, Including Extracellular Vesicles, to Improve the Diagnostic Accuracy of Cardiac Assessment by Stress Echocardiogram.

Principal Investigator (PI): Dr Azeem Sheikh

ZODIAC: OptimiZation of Lipid Lowering Therapies Using a DSS in ACS: Implementation of a Decision Support System and its Effect On Early Optimisation of Lipid-Lowering Therapies in Patients with Acute Coronary Syndrome: A Cluster Randomised Controlled Trial.

Principal Investigator (PI): Dr Azeem Sheikh

ORION-4:A Double-Blind Randomised Placebo-Controlled Trial Assessing the Effects of Inclisiran On Clinical Outcomes Among People with Atherosclerotic Cardiovascular Disease.

Principal Investigator (PI): Dr Sabari Haridass

Gastroenterology

CLARITY IBD: Impact of Biologic Therapy on SaRs-Cov-2 Infection and Immunity. 

Principal Investigator (PI): Dr Sunil Sonwalkar

M14-533: A Phase 3 Multicenter, Open-Label Extension (OLE) Study to Evaluate the Long-Term Safety and Efficacy of ABT-494 in Subjects with Ulcerative Colitis.

Principal Investigator (PI): Dr Sunil Sonwalkar

Endocrinology

IS354CS5: A Randomised, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia.

Principal Investigator (PI):Dr Sabari Haridass

Maternity

CHAPTER: Childbirth Acquired Perinatal Trauma Study; a Cohort Study.

Principal Investigator (PI): Dr Tina Verghese

GBS3: The Clinical and Cost-Effectiveness of Testing for Group B Streptococcus: A Cluster Randomised Trial with Economic and Acceptability Evaluations.

Principal Investigator (PI): Dr Julie Goddard

SUNNY:A Randomised Controlled Trial to Investigate the Feasibility and Acceptability of Snacktivity™ in Pregnant Women.

Principal Investigator (PI): Ms Melanie Struthers

 

Ophthalmology

ATHENA: Optical Coherence Tomography Angiography for the Detection of Neovascular Age-Related Macular Degeneration: A Comprehensive Diagnostic Accuracy Study.

Principal Investigator (PI): Ms Indra Dias

GALE: A Phase 3 Open-Label, Multicenter, Extension Study to Evaluate the Long-Term Safety and Efficacy of Pegcetacoplan in Subjects with Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Principal Investigator (PI): Ms Indra Dias

Paediatrics

AZTEC2: Long Term Follow-Up of Azithromycin Therapy for Chronic Lung Disease of Prematurity The AZTEC 2 (Azithromycin Therapy for Chronic Lung Disease 2) 

Principal Investigator (PI): Dr James Houston

Azithromycin Therapy for Chronic Lung Disease of Prematurity: A Randomised, Placebo Controlled Trial of Azithromycin for the Prevention of Chronic Lung Disease of Prematurity in Pre-Term Infants.

Principal Investigator (PI):Dr James Houston

Genetic Determinants of Kawasaki Disease: Genetic Determinants of Kawasaki Disease for Susceptibility and Outcome.

Principal Investigator (PI): Dr Khaleel-Ur Rahman

SINEPOST:SARS-CoV-2 Infection in Neonates or in Pregnancy: Outcomes at Eighteen months.

Principal Investigator (PI):Mrs Georgina Turner

CF START: The Cystic Fibrosis (CF) Anti-Staphylococcal Antibiotic Prophylaxis Trial (CF START), A Randomised Registry Trial to Assess the Safety and Efficacy of Flucloxacillin as a Long-Term Prophylaxis Agent for Infants with CF.

Principal Investigator (PI): Dr James Houston

Physiotherapy

WISE: Wrist Injury Strengthening Exercise: Progressive Resistance and Flexibility Exercises Versus Usual Care Advice for Improving Pain and Function After Distal Radius Fracture in Adults Aged 50 Years or Over: the WISE Randomised Superiority Trial.

Principal Investigator (PI): Ms Claire Paxman

Radiology

MIDI: Deep Learning for Identification of Abnormalities on Head MRI.

Principal Investigator (PI):Mrs Georgina Turner

Sexual Health

C2C: COMBINE-2 for Cabotegravir+Rilpivirine LA Regimen.

Principal Investigator (PI): Dr Emma Street

DEVA: Dequalinium Versus Usual Care Antibiotics for the Treatment of Bacterial Vaginosis. 

Principal Investigator (PI): Dr Emma Street

 

Stroke

ENRICH-AF: Edoxaban for IntraCranial Haemorrhage Survivors with AF.

Principal Investigator (PI):Dr Syed Ahmad

OPTIMAS: Optimal Timing of Anticoagulation After Acute Ischaemic Stroke: A Randomised Controlled Trial.

Principal Investigator (PI): Dr Manohar Kini

Surgical

RECOVER TOGETHER: Improving Recovery After Bowel Cancer Surgery: Mixed-Method Feasibility Study of a Co-Produced Information Intervention.

Principal Investigator (PI): Ms Claire MacDonald

Trauma & Orthopaedics

PROFHER2: A Three-Arm Randomised Controlled Trial to Assess the Effectiveness and Cost-Effectiveness of Reverse Shoulder Arthroplasty Versus Hemiarthroplasty Versus Non-Surgical Care for Acute Three and Four-Part Fractures of the Proximal Humerus in Patients Over 65 Years of Age – Proximal Fracture of the Humerus: Evaluation by Randomisation Trial No.2.

Principal Investigator (PI):Mr Neil Pennington

WHITE 10 LIT: World Hip Trauma Evaluation Appendix 10 – LIT: Lidocaine Intravenous Trial.

Principal Investigator (PI):  Dr Andreea Jiminez